Isis Pharmaceuticals, Inc. (Nasdaq:ISIS), the leader in antisense therapeutics, announced that management will present a company overview at Stifel Nicolaus' Healthcare Conference 2011 on Thursday, September 08, 2011 at 2:05 p.m. ET at the Four Seasons Hotel in Boston. A live audio webcast of the presentation will be available on the "Investors & Media" section of the Company's Web site, www.isispharm.com. A replay of the presentation will be available on the Isis Web site within 48 hours and will be archived for a limited time.

Isis is exploiting its leadership position in antisense technology to discover and develop novel drugs for its product pipeline and for its partners. Isis' broad pipeline consists of 24 drugs to treat a wide variety of diseases with an emphasis on cardiovascular, metabolic and severe and rare/neurodegenerative diseases, and cancer.

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