Catalyst Pharmaceutical Partners Inc. (NASDAQ:CPRX)

CPRX recently announced that a poster presentation demonstrating that CPP-115, Catalyst's next-generation GABA aminotransferase inhibitor, suppresses infantile spasms (IS) in the rat multiple-hit model will be made on December 3, 2011 at the American Epilepsy Society's 65th Annual Meeting (AES) to be held December 2-6, 2011 at the Baltimore Convention Center in Baltimore, Maryland.

IS is an infantile epileptic encephalopathy associated with cognitive and behavioral deficits and increased mortality. Vigabatrin (CPP-109), a GABA transaminase inhibitor, is one of the few treatments available for IS. The study tested the efficacy in suppressing spasms and tolerability profile of Catalyst's new vigabatrin analog, CPP-115, in the multiple-hit rat model of ACTH-refractory symptomatic IS (DLP model). This model recreates the spasms, ictal EEG correlates, interictal EEG abnormalities, and neurodevelopmental decline observed in symptomatic infantile spasms observed in babies. In the later stages of development, the rats also develop learning, memory, and autistic like deficits similar to those observed in humans. It is therefore, currently one of the best models available for the evaluation of pharmacotherapies for the treatment of ACTH resistant infantile spasms. In previous studies, vigabatrin only transiently suppressed spasms in the DLP model (postnatal day 5 (PN5) only), but was associated with increased sedation and consequently mortality due to poor feeding. The poster describes the following study conclusions:

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